China-Vacuum-Lyophilizer

Lyophilizer is used for pharmaceutical, food, bio product, blood product, vegetable and other goods.

1. CHAMBER
The chamber will be horizontal parallelepiped or cylindrical design, in which the shelf package is located, with all the edges and corners rounded off to facilitate cleaning, as specified by cGMP. It is designed for high vacuum application as well as to withstand overpressure during steam sterilization.

Chamber is equipped on its one side with an illuminated viewing port, and inner part made of AISI 316L stainless steel and borosilicate glass, for inspection from the machine room.

The chamber bottom is sloped towards the rear part, where there is a drainage outlet, in order to ease the cleaning of the chamber either with water for injection or with an eventual integrated CIP.

All ports and piping connections are clamp sanitary type. At one side or on top of the chamber there is a clamp port as a reservation for validation, such as steam sterilization process, pressure, temperature and so on.

The chamber is fitted with a means for lifting to assist handling and installation.

Generally, the following connections are provided:

Isolation valve, inlet and outlet of thermal fluid, inlet and outlet of steam and cleaning water, hydraulic flange (for shelves movement only), reservation port for validation, illuminated view port and drain.

Generally, for big machine, more than 5sq. M, the chamber wall is provided with a jacket to cool after sterilization.

2. DOOR
The door is clad in polished stainless steel AISI 316L, roughness of average less than 0.5um, to provide a clean smooth finish. In the center part height about 1.5m, there is a viewing port, made internally of AISI 316L stainless steel and borosilicate glass, for inspection from the clean room.

Door sealing is, with a T-shaped or O-shaped solid single silicone or fluorine material with air-release free gasket designed for high vacuum and overpressure operation, placed in the chamber frame. The door presses on gasket to make it the same level with the chamber internal surface under vacuum, so that there is no collective water around this area during CIP and SIP.

There are two safety interlock devices to check the situation of locking. One is a limited switch; The other is latch feedback signal. In case of any failure, the process of CIP or SIP cannot run. Whats more, temperature and pressure are interlock to protect the operator and machine.

A flat sterile wall flange with stainless steel 304, surface on clean room side roughness of average less than 0.75um, is connected with the rear sterile wall by flexible gasket sealing.

3. SHELVES
Shelves are built in AISI 316L stainless steel and they are ground smooth finish to a roughness of average less than 0.5m. With internal channeling for product freezing and subsequent heating by circulation of thermal fluid. Direct contact of the fluid on both faces of the shelf and high flow-rate through the channeling ensure excellent temperature uniformity at all points on all shelves.

Shelf temperature range can be controlled between 55º C and +70º C depending on the lyophillization step being performed. There are several temperature sensors for monitoring the product temperature and the number of sensors depends on customer requirements. The sensor with enough lengths cable will be for flexible movement, so that it can be inserted to any product container on any shelf. Meanwhile there are two temperature sensors located at the silicone oil inlet and outlet separately to measure the shelves temperature.
Above the top useable shelf there is an extra-unloaded shelf to thermally balance the complete assembly.
Model Unit 1 3 5 10 15 20 30
Usable shelf area M 2 1.08 3.24 5.40 10.8 15.8 21.6 29.7
Ice capacity kg 22 65 100 220 300 420 620
Shelf dimension mm 600*450 900*600 1200*900 1200*900 1200*1200 1500*1200 1800*1500
Shelf number Pcs 4 6 5 10 11 11 11
Shelf space mm 100
Shelf temperature ºC -55 ~ +88
Condenser min. temp. ºC -75
Limit vacuum Pa 1
Pure steam consumption Kg/h 30 50 80 150 200 260 320
Washing water L/m 60 160 210 320 360 500 620
Power Kw 15 30 36 65 80 120 138
Cooling water T/h 3 6 8 20 26 35 45
Compressed air m 3 /m 0.1(6-8 bar)
Dimension (LxWxH) M 2.5*1.0*2.3 4.5*1.8*3.0 4.9*1.8*3.3 5.6*2.0*3.5 5.8*2.2*4.0 6.8*2.3*4.1 8.5*2.4*4.2
Weight Ton 2.2 5 7 10 13 16 23
Loading capacity
Dia.=16mm(2ml vial)
pcs 4,800 15,000 22,000 40,000 63,000 86,000 120,000
Loading capacity
Dia.=22mm(10ml vial)
pcs 2,450 7,500 11,000 20,000 33,200 43,200 60,000
Loading capacity
Dia.=28mm(20ml vial)
pcs 1,800 4,300 6,100 13,600 16,000 22,000 38,000

Highlights of our Freight Elevator
The unique operation model
The unique operation model can ensure the speed, improve the comfort and leveling accuracy and reduce the
 running noise.
The solid and durable freight elevator car
High strength material is used in the freight elevator car to make sure the solid and durable elevator car can work in different severe environments
Wide door opening distance
Multiple folding door is adopted to achieve the maximum opening width and esay moving in and out of large goods.
Excellent torque characteristics
The biggest characteristic of DESENK freight elevator is the constant torque characteristic, and has no effect on spped, load, comfortable feel or leveling accuracy

Machine Room Freight Elevator

Machine Room Freight Elevator, Machine Room Freight Lift, Machine room Elevator for Production Line, warehouse freight elevator

Shandong Bester Elevator Co., Ltd. , https://www.besterlift.com